Scleroderma, which means “hard skin,” is a rare disease that causes tissue to become hard and thick. Affected areas usually include the skin on the arms, legs, or trunk. Scleroderma can also cause swelling or pain in the joints and muscles. In severe, life-threatening forms, tissues of the lungs, heart, kidneys, or other internal organs can also be damaged. Researchers believe the disease may be caused by your immune system attacking your own body. To manage symptoms, doctors often prescribe cyclophosphamide, an immune-suppressing drug.

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